Furosemide and food
Abstract/Summary
Food reduces the bioavailabiltty of Furosemide and its diuretic effects
Clinical evidence
10 normal subjects were given 40 mg Furosemide at 8 00 am with and without breakfast (milk, roll, cheese, butter, egg). The food reduced the peak serum levels by 55% (from 933 to 423 ng/ ml) and the bioavailabihty was reduced approximately 30%. The results were almost identical in five other subjects given a heavy meal (avacado with cream, fish, potatoes, fruit salad). The diuresis over 10 h was reduced by 21% (from 2072 to 1640 ml) and over 24 h by 15% (from 2668 to 2270 ml). When these figures were compared with urinary output of other subjects who were not given Furosemide, the increased amount of urine when the Furosemide was given without breakfast was about 600 ml whereas the increase was only 200 ml when given with breakfast, representing an approximately two-thirds reduction.
Another study also found a reduction in the urinary recovery of Furosemide.
Mechanism
Not understood
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